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In people with both type 2 diabetes and obesity, an indirect comparison drawing on the separate SURMOUNT-2 (NCT04657003) and STEP 2 (NCT03552757) trials, rather than a single head-to-head study, reported weight reduction of up to 15.7% with tirzepatide and 10.6% with semaglutide 2.4 mg

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But, as the NYT notes, though the 14 peptides were technically restricted by the government (meaning compounding pharmacies were not allowed to produce them), consumers could still purchase them via the online gray market and play doctor from the comfort of their kitchen