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observed that a combined administration of low doses of tryptophan (500 mg), niacin (100 mg), calcium (500 mg calcium carbonate), caffeine (64 mg), and acetylsalicylic acid (ASA) (650 mg) shortly after migraine attack resulted in beneficial effects in 9 out of 12 migraine patients (42)

The episode uses the conservative end of this range as the most defensible estimate of the real population-level rate after accounting for assay drift

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doi: 10.1186/s13018-019-1242-6