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All participants fasted overnight before the OCCT and were requested to avoid red meat, seafood, or any medication during the test

The GIP receptor activation appears to reduce nausea compared to pure GLP-1 agonists, which is why retatrutide shows a 28% nausea rate versus 44% for semaglutide despite being more potent

If you do choose to drink, a few boring-but-effective moves reduce the compounded sedation: eat something first, alternate each drink with water, and pace yourself slowly

There had been concerns about these drugs because theyre prescribed to treat type 2 diabetes, a condition associated with pancreatic cancer

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