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In addition, as an HDAC inhibitor, butyrate maintains specific protein PTMs by blocking deacetylase activity

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Sci Rep 7 , 41085 (2017)

Both aerobic activities (like walking or cycling) and resistance training (like weight lifting) have been shown to improve the bodys sensitivity to GLP-1, supporting appetite control

In this way we can avoid starting insulin, improving the patient's quality of life and his/her compliance and reducing the cost of anti-diabetic therapy

For this reason, I would always also assess for low serotonin and low GABA and do trials of tryptophan or 5-HTP for low serotonin and GABA for low GABA