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Avoiding Glutathione-Depleting Foods and Substances Just as important as consuming glutathione-supporting foods is minimizing intake of substances that deplete glutathione or increase oxidative burdens

4,5 Dietary insufficiency, pernicious anemia (i.e., an autoimmune process that reduces available intrinsic factor and subsequent absorption of vitamin B 12 1,2,6,7 ), and long-term use of metformin or acid-suppressing medications have been implicated in B 12 deficiency