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Converts white adipose tissue into brown adipose tissue (a phenomenon called fat tissue browning) to prevent body disfigurement associated with obesity and overweight

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However, it would be interesting to see if similar bias occurs at central GLP-1r populations and whether this alters the synaptic and behavioral outcomes of GLP-1r agonism

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This upregulation leads to an increased expression of lipogenic genes, including sterol regulatory element-binding proteins (SREBP1c) and diacylglycerol acyltransferase-2 (DGAT2), which suggests that miR-370 provides a further point of regulation of this pathway 86

While this concept had been explored by academic groups and other pharmaceutical companies, Eli Lilly was uniquely positioned to execute it given their experience engineering multi-receptor peptides