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That is not safe

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In fact, of the nearly half a million adults on GLP-1s, more than 60% consume below estimated requirements for calcium and iron and vitamin D intake averaged just 20% of recommendations, according to a 2026 narrative review in Clinical Obesity

When appropriate, tapering the medication under a clinician's guidance can make the transition less jarring

This acylation is what gives it its extended half-life of approximately six days, allowing for once-weekly dosing

However, they differ in a key way: tirzepatide is a dual agonist (GLP-1 and GIP), while retatrutide is a triple agonist (GLP-1, GIP, and GCG)