J Am Soc Nephrol JASN
The concept that an increase in the LBP may increase ligand promiscuity was further supported by biochemical studies in which threonine was replaced by the larger amino acid aspartic acid, which prevented androgen binding, presumably by steric hindrance, making the mutant receptor unresponsive to androgen activation 166
Tohoku J Exp Med 221:191195 Xu S, Waddell J, Zhu W, Shi D, Marshall AD, McKenna MC, Gullapalli RP (2015) In vivo longitudinal proton magnetic resonance spectroscopy on neonatal hypoxic-ischemic rat brain injury: neuroprotective effects of acetyl-l-carnitine
Using density functional theory calculations, the catalytic cycle of the ruthenium catalyst is predicted
However, alternative oxygen concentrations, such as 1% or 5%, were not investigated, leaving it unclear whether the effects observed are specific to the 3% condition or indicative of a more general hypoxia-dependent response
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