References Ohno T, et al
Notably, the extent of weight loss achieved with GLP-1 RA therapy may be directly linked to the degree of reduction in preference for high-calorie foods as semaglutide was associated with reduced cravings for both savory and sugary foods, with decreases in craving scores correlating with greater weight loss (Blundell et al., 2017
Marx N, Federici M, Schutt K, et al
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Weeks 1-4: 1mg weekly (4mg total, small portion of first vial) Weeks 5-8: 2mg weekly (8mg total) Weeks 9-12: 4mg weekly (16mg total, finish first vial and start second) Weeks 13-16: 6mg weekly (24mg total, continue through second vial) Weeks 17-20: 8mg weekly (32mg total) Weeks 21-24: 8mg weekly maintenance (32mg total) Total peptide required: 116mg over 24 weeks Vials needed: 6 x 20mg vials with some remaining This protocol reaches 8mg maintenance by week 17 and holds there through week 24
The London study involved a combination of healthy volunteers as well as patients who had previously had part of their stomach removed because of cancer who were in good health