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Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

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Comparing the binding modes of these natural inhibitors in hTYR and mTYR, it is evident that when searching for inhibitors for mTYR, smaller molecules or short peptides with elongated backbones are more desirable

Pellegrini A, Hgeli G, von Fellenberg R: Isolation and characterization of three protein proteinase isoinhibitors from the granular fraction of horse neutrophilic granulocytes