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This was associated with its function as a stabilizer of cellular junction [5], leading to significantly mitigated indomethacin-induced leaky gut syndrome, via increasing tight junction protein ZO-1 expression, and transepithelial resistance [5]

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For observational studies in Table 1 ( n = 11), formal standardized risk of bias assessment was not conducted due to substantial heterogeneity in study designs, participant characteristics, laboratory methods, and outcomes measured

Vitamin B6 supports testosterone production by reducing prolactin levels, acting as a cofactor in steroidogenesis enzymes, and modulating androgen receptor sensitivity

However, short-term NSAID use (few days) unlikely causing significant problems