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this IDS-SR 30 anhedonia subscale has been previously demonstrated to highly correlate with the self-administered and clinician-administered versions of the SHAPS [42] and replicated in other samples [40]

notably, it inhibits NF-B activation, thereby reducing pro-inflammatory cytokines and mediators such as COX-2 and iNOS in the tumor microenvironment

In laboratory work it stimulates dermal fibroblasts, the cells that build the skin's supporting matrix, and it influences the production of collagen and other components of that matrix

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