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Furthermore, in a study of NA supplementation with a dose of 207.5 mg NA per day for 32 days to older adults with impaired physical function, no improvements in NAD + or mitochondrial functions in skeletal muscle were observed 321

This was similar to the effects of metformin on PCOS

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Stress, poor sleep, alcohol, intense exercise, travel, environmental exposures, and even blood sugar swings can all increase oxidative load

[DOI] [PubMed] [Google Scholar] 136.Lakso HA, Wuolikainen A, Sundkvist A, Johansson I, Marklund SL