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Figure 6 (A1) and (A2) depict the normal parenchyma morphology, featuring oval-shaped cells with prominent nucleoli and pale basophilic cytoplasm, devoid of significant gliosis, edema, neuronal loss, or congestion of meningeal vessels

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Dysfunction of mitochondria and increased levels of oxidative stress in the brain, neuronal cell cultures, urine, and erythrocytes have been confirmed in individuals with Down syndrome (Jovanovic et al

He is also on the staff of Greenwich Hospital and New York (Columbia) Presbyterian Hospital