retatrutide nejm 2023 obesity trial ly3437943 Triple hormone receptor agonist for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a As an obesity medicine physician,

A distinction should be made between melanosis, as the pigmentation of mucosae from the deposit of melanin in the macrophages-lysosomes at the level of the lamina propria, and pseudomelanosis, described as a pigmentation of the mucosae secondary to deposits of iron, ferrous sulfide, hemosiderin, lipomelanin, lipofuscin, calcium, potassium, aluminum, magnesium, and silver at the same level.1 After a review of the medical literature, we found reports of cases with pseudomelanosis secondary to the deposit of iron mainly at the level of the duodenum, with a predominance in Afro-American women in the seventh decade of life (range of 18 months -79 years).25 Important pigmentation pathology references at the level of the digestive tract include melanosis coli, which is the deposit of pigments at the level of the colon mucosa associated with the abuse of oral laxatives,6 and melanosis at the level of the esophagus, ileum, jejunum, peritoneum, cecal appendix, mesenteric lymph nodes, and the duodenum

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