Damaging broccoli sprouts when chewing, chopping, or freezing triggers an enzymatic reaction in the tiny plants that produces sulforaphane
Each component consists of defined amino acid sequences associated with specific cellular signaling pathways
It was originally created by researchers at the University of Arizona in Tucson, AZ, In the early 1990s to increase melanin production and serve as a potential protectant from ultraviolet (UV) light-induced skin cancers
This functional unit strictly depends on the integrity of the gut epithelium, supported by junctional proteins, such as tight junctions (TJs), desmosomes, and adherent junctions, which form a physical barrier and connect adjacent epithelial cells, together with the lamina propria
For example, mixing 10 ml of bacteriostatic water into a 5 mg vial produces a 0.5 mg/ml solution so a "25-unit dose" on a U-100 syringe now delivers only 0.125 mg, half the intended amount
J Am Acad Dermatol 49 : 407412 Ethics declarations Competing interests JA Neville completed a study sponsored by 3M Pharmaceuticals and has presented this work at symposia on behalf of this company
