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The CagriSema metabolic preservation mechanism, specifically the maintenance of mitochondrial function in skeletal muscle during weight loss, could theoretically slow the rate of weight regain by preventing some of the metabolic adaptation that makes regain almost inevitable

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This lifting action reduces back strain and prevents that uncomfortable skin-on-skin friction that often leads to rashes and infections

Venous blood samples were stored at 20 C in polypropylene tubes until analysed, 80 L of ethylenediaminetetraacetic acid (EDTA) plasma was used to assess cagrilintide pharmacokinetics at each timepoint, thus 16 mL EDTA plasma from each participant was used

Results from these clinical trials were promising, showing that the combination therapy was well-tolerated and effective