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In some particular embodiments of the present invention, in the preparation method, for Boc-His(Trt)-OH, the coupling is performed by a B+A+C system

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Adults with overweight or obesity who were dispensed tirzepatide or semaglutide for type 2 diabetes treatment from May 2022 to September 2023 had a baseline weight measurement available within 60 days before the first medication dispense and had not used a GLP-1 receptor agonist in the past were included