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Once in the nucleus, it binds to specific transcription factors and DNA elements particularly antioxidant response elements (ARE) that are regulated by the stress-responsive factor NRF2. Through this mechanism, MOTS-c can turn on a suite of stress-defense and metabolic genes that help cells adapt to high-fat stress or insulin resistance

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Half-life Not established in humans no published human pharmacokinetic study exists

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In vitro studies have shown that monomeric flavanols stimulate ghrelin secretion, while oligomeric flavanols and gallic acid inhibit it (7577)