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Data on common gastrointestinal side effects of different incretin-based therapies compared to placebo, pooled from other published systematic reviews and meta-analyses, highlights the lowest OR for nausea, vomiting, and diarrhoea with cagrilintide [Table 4].[22,24] Therefore, cagrilintide can be considered a promising therapeutic option for weight loss in obese individuals who may not tolerate GLP1RAs or have a lower tolerance for nausea and vomiting

the drug was discontinued in 3.6% of the persons in the CagriSema arm compared to 1.3% in the comparators' arms, and observed gastrointestinal adverse events per patient per year were 2.8 with CagriSema versus 2.6 with semaglutide 2.4 mg monotherapy [125]

[DOI] [PMC free article] [PubMed] [Google Scholar] 201.Shen Q., Shen Y., Jin F., Du Y.Z., Ying X.Y

33 ItohK.WakabayashiN.KatohY.IshiiT.IgarashiK.EngelJ

doi: 10.1038/s41598-017-15668-z 61 YeePPWeiYKimSYLuTChihSYLawsonCet al