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DOI: 10.1172/JCI5461

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The recent discovery of pharmacological ABHD5 ligands that disrupt the interaction between ABHD5 and PLIN1 (48) demonstrate that the dissociation of ABHD5 is sufficient to stimulate adipocyte lipolysis and that these protein interactions can be targeted pharmacologically (34, 48, 49)

The approach has been validated through extensive clinical research demonstrating that selectivity can be achieved without sacrificing efficacy for the targeted application

The result is reduced appetite and, over time, significant weight reduction in clinical studies

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