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In addition, prescriptions to any individuals with diabetes were removed to increase the likelihood that all prescriptions were for weight loss

For the side effect phenotypes, the effect size represents log-odds ratio, whereas for the efficacy phenotype, the effect size represents percentage BMI change

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Two robust regression LME models (package(nlme)(Pinheiro et al., 2023)) were estimated for each brain region to investigate the relationship between metabolite (GSH or GABA+) levels and diagnosis group, age, and sex, accounting for the random intercept of each participant

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