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GLP-1 medications typically show initial effects on blood glucose within 1 to 2 weeks and appetite suppression within days to weeks, but reaching full therapeutic response takes longer as doses gradually increase

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Extended gaps can affect your tolerance, and restarting at your previous dose after a prolonged break may produce more intense side effects than expected

Tirzepatide (Zepbound for weight loss, Mounjaro for diabetes), liraglutide (Saxenda), and older agents such as phentermine-topiramate (Qsymia) are also possibilities