The day of weekly administration can be changed, if necessary, as long as the time between the 2 doses is at least 3 days (72 hours)
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Increasing levels of VitB12 in humans have been shown to lead to a decline in 24-h mean melatonin levels and nocturnal melatonin levels during bright-light exposure, thereby disrupting the sleep-wake cycle toward increased alertness and decreased sleep duration [21, 38]
Encapsulation may also reduce compound degradation during storage, offering extended shelf life compared to reconstituted solutions
Finally, due to the nature of cross-sectional study designs, we cannot interpret the causality of the observed association between VitB12 and insomnia