The construction documents are now complete and the project will go out to bid in early 2024
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Briefly, SH-SY5Y cells were incubated with UDE containing 1, 10, and 100 M -EC for 4 h, then treated with H 2 O 2
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Peripherally derived bile acids primarily reflect hepatic metabolism and microbiota-dependent transformations, entering the CNS through passive diffusion (unconjugated species such as CA, CDCA, DCA) or active transport mediated by ASBT, OATP, and OST/ (conjugated species), thereby coupling central signaling to systemic metabolic states, circadian rhythms, and composition of intestinal microbiota [64,65,83]