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Estrogen can also increase the expression of PDZ domain protein kidney-1 (PDZK-1) which can enhance melanogenesis and melanosomes transfer (Lee, 2015)

[113] demonstrated that in the eyes of aged mice, the increased signaling of the STAT3 pathway induced the M2 polarization of macrophages, thus enhancing vascular proliferation and subsequently the formation of angiogenesis

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Makena P, Kikalova T, Prasad GL, Baxter SA

In addition, DCDNO2 can accurately assist and guide the surgical removal of tumors after local spraying of DCDNO2 in mouse models of liver cancer (Fig

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