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producing high-avidity binding that substantially exceeds the affinity of monovalent GalNAc ligands and closely mimics the geometry of clinically validated Tri-GalNAc targeting moieties used in approved GalNAc-siRNA therapeutics
β-D-Gal-Butyl-Carboxylic Acid
/ Fmoc-Ser(GlcNAcβ(1-3)GalNAc)-OH (Peracetate) / Core 3 O-Glycan on Serine
4-Methylumbelliferyl (MU) glycosides are fluorogenic enzyme substrates: cleavage of the glycosidic bond by the target enzyme releases free 4-methylumbelliferone
Terminal α-Gal residues are also a substrate for glycosyltransferases and relevant to studies of the α-Gal epitope (Galα1-3Gal) and anti-Gal antibody recognition
ES911020: 4-Nitrophenyl 6-O-α-D-Glucopyranosyl-α-D-Glucopyranoside Pack Size:25 mg producing high-avidity binding that substantiallyC18H25NO13 463. 39 A 4 nitrophenyl glycoside of isomaltose (Glc1 6Glc), an 1 6 linked glucose disaccharide. Used as a chromogenic substrate for glucosidases and isomaltases with 1 6 linkage selectivity (e. g., sucrase isomaltase, oligo 1,6 glucosidase, and other debranching glucosidases); enzymatic cleavage of the aglycone proximal glucosidic bond releases 4 nitrophenol. 4 Nitrophenyl (pNP) glycosides are chromogenic enzyme substrates: cleavage of the
